Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population

Abstract Background The prevalence and genotypes of G6PD deficiency vary worldwide, with higher in malaria endemic areas. first-time assessment molecular characterization mutations the Lao Theung population were performed this study. Methods A total 252 unrelated participants residing People’s Democratic Republic (PDR) recruited. All participant samples tested for enzyme activity gene mutations. amplification refractory mutation system (ARMS)-PCR detecting Aures was developed. Results detected 11.51% (29/252) participants. Eight detected. most common identified cohort, which represented 58.62% (17/29) all mutation. pattern homogenous, predominantly involving (6.75%), followed by 1.19% Union 0.79% each Jammu, Mahidol Kaiping. One subject (0.4%) carried Viangchan Canton. Interestingly, one case coinheritance Quing Yan cohort. Based on levels activity, 9.13% (23/252). deficient males females (activity < 30%) 6.41% (5/78) 1.72% (3/174), respectively, intermediate 30–70%) 5.95% (15/252). Conclusions is highly prevalent ethnic group. variants continental Southeast Asian populations, Viangchan, Canton, Kaiping, Mahidol, not technical simplicity developed ARMS-PCR will facilitate final diagnosis Aures.